It is secreted from the pineal gland in response to darkness which conveys to the brain that it is time to go to bed.🌙😴
Mind you it is produced in picograms, and we use it in milligrams!
Melatonin is the primary medication for insomnia as per AAFP ( American Academy of Family Physicians) even though it is not FDA approved.

Best indications would be;
Any circadian rhythm issues such as jetlag, night work, when other lifestyle modifications don’t help, aging-related sleep issues, some neurodegenerative diseases…
Ideally better used briefly and at low doses….

Melatonin interferes with the immune system –> upregulates Th2 which may increase the risk of RA (rheumatoid arthritis)
When used in long term, it is noted to adversely affect fertility in men; also has Central Nervous System side effects- drowsiness etc
Here is a link to a recent review on Melatonin;
https://www.ncbi.nlm.nih.gov/books/NBK534823/

#sleepwell
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